Orciprenaline sulfate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种 β2 肾上腺素能激动剂，用于治疗哮喘和支气管痉挛。

A beta-2 adrenergic agonist used in the treatment of asthma and bronchial spasm.(In Vitro):Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.(In Vivo):Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.

Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages. Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to down regulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages. Western Blot Analysis Cell Line:THP-1 cells and bone marrow macrophages Concentration:10 μM Incubation Time:74 hoursResult:Enhanced β-arrestin2 and its interaction with IκBα.RT-PCR Cell Line:THP-1 cells and bone marrow macrophages Concentration:10 μM Incubation Time:74 hours Result:Led to downregulation of NF-κB.

Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.

dl-Metaproterenol | dl-Orciprenaline

Endocrinology/Hormones

Adrenergic Receptor

β-adrenergic receptor

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5874-97-5

260.3

C11H17NO3·0·5H2O4S

>98% (HPLC)

DMSO: 10 mM

OC1=CC(OS(=O)(O)=O)=CC(C(O)CNC(C)C)=C1

3-hydroxy-5-(1-hydroxy-2-(isopropylamino)ethyl)phenyl hydrogen sulfate

(-20℃)

With Ice Pack

≥ 2 years